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Table 2 Univariate and multivariate analyses of factors associated with RFS and DSS

From: Prognostic significance of classified extramural tumor deposits and extracapsular lymph node invasion in T3–4 colorectal cancer: a retrospective single-center study

  Colon Rectum
Factor RFS DSS RFS DSS
Univariate Multivariate Univariate Multivariate Univariate Multivariate Univariate Multivariate
P P P P
Age (years): ≥70 0.75 0.59 0.23 0.045 0.70
Gender: male 0.47 0.68 0.35 0.22
CEA (ng/ml): >5 0.50 0.69 0.24 0.34
pT: 3 vs. 4 0.0029 0.66 <0.0001 0.0026 0.33 0.14
Tumor size (cm): <5 0.49 0.46 0.054 0.47 0.75
Histology: well/moderate 0.71 0.49 0.51 0.48
pN: (+) 0.0005 0.84 0.021 0.47 <0.0001 0.079 0.22
Total LNs count: <12 0.41 0.95 0.03 0.062 0.23
LN ratio: >0.29 <0.0001 0.73 0.40   <0.0001 0.65 0.026 0.67
Lymphatic invasion: (+) 0.23 0.51 0.045 0.36 0.38
Venous invasion: (+) 0.034 0.14 0.13 0.18 0.24
Chemotherapy: (−) 0.13 0.031 0.35 0.53 0.39
iTD: (+) <0.0001 0.052 0.0038 0.32 <0.0001 0.0039 <0.0001 0.021
nTD: (+) <0.0001 0.075 0.26 0.017 0.047 0.65
ECLNI: (+) 0.0013 0.02 0.22 0.093 0.025 0.31
  1. RFS relapse-free survival, DSS disease-specific survival, CEA carcinoembryonic antigen, LN lymph node, iTD invasive-type tumor deposits, nTD nodular-type tumor deposits, ECLNI extracapsular lymph node invasion
  2. Bold text indicates statistically significant P-values (<0.05)