Table 2 Univariate and multivariate analyses of factors associated with RFS and DSS

Age (years): ≥70

0.75

–

0.59

–

0.23

–

0.045

0.70

Gender: male

0.47

–

0.68

–

0.35

–

0.22

–

CEA (ng/ml): >5

0.50

–

0.69

–

0.24

–

0.34

–

pT: 3 vs. 4

0.0029

0.66

<0.0001

0.0026

0.33

–

0.14

–

Tumor size (cm): <5

0.49

–

0.46

–

0.054

0.47

0.75

–

Histology: well/moderate

0.71

–

0.49

–

0.51

–

0.48

–

pN: (+)

0.0005

0.84

0.021

0.47

<0.0001

0.079

0.22

–

Total LNs count: <12

0.41

–

0.95

–

0.03

0.062

0.23

–

LN ratio: >0.29

<0.0001

0.73

0.40

<0.0001

0.65

0.026

0.67

Lymphatic invasion: (+)

0.23

–

0.51

–

0.045

0.36

0.38

–

Venous invasion: (+)

0.034

0.14

0.13

–

0.18

–

0.24

–

Chemotherapy: (−)

0.13

–

0.031

0.35

0.53

–

0.39

–

iTD: (+)

<0.0001

0.052

0.0038

0.32

<0.0001

0.0039

<0.0001

0.021

nTD: (+)

<0.0001

0.075

0.26

–

0.017

0.047

0.65

–

ECLNI: (+)

0.0013

0.02

0.22

–

0.093

0.025

0.31

–