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Table 1 Changes in the expression of individual isoforms of the Androgen Receptor in our cell line model and in the human tumour data. No significant differential expression is seen in either dataset. Transcripts are taken from the Ensembl AR Gene Transcript Table (ENSG00000169083)

From: Network analysis of an in vitro model of androgen-resistance in prostate cancer

Transcript Identifier HGNC transcript name Protein length Domains Cell Line Log Fold-Change Cell Line P-Value Tumour Log Fold-Change Tumour P-Value
ENST00000374690 AR-001 920aa NTD, ZF, LBD 0.03 0.95 0 1
ENST00000396043 AR-002 388aa ZF, LBD 0 1 −0.11 0.92
ENST00000513847 AR-003^ - - 0.72 1 0 1
ENST00000504326 AR-004 (AR-V7) 644aa NTD, ZF −1.38 0.57 1.82 0.69
ENST00000514029 AR-005* 600aa NTD, ZF(partial) −0.19 1 0 1
ENST00000396044 AR-201 734aa ZF 0 1 −0.08 0.96
ENST00000612010 AR-202 642aa NTD, ZF ND ND ND ND
ENST00000612452 AR-203 737aa NTD (partial), ZF, LBD ND ND ND ND
ENST00000613054 AR-204 572aa NTD ND ND ND ND
  1. *Nonsense mediated decay; ^Processed transcript; ND not detected, NTD N-terminal domain, ZF zinc finger, LBD ligand binding domain. AR-004 is identified as the AR-V7 transcript based on the description of the isoform provided by Krause and colleagues (2014), as the protein encoded by this transcript aligns to the first 627aa of the full length AR, and contains 15 unique amino acids, with one overlapping a splice site [19]