Table 2 Accuracy of detecting CIN2+ for different sampling media in combination with three HPV testing methods
Methods | Sampling Medium | HPV Prevalence | Accuracy | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
(%) | Sensitivity | Specificity | Positive Predictive Value | Negative Predictive Value | ||||||
% (n/N) | 95 % CI | % (n/N) | 95 % CI | % (n/N) | 95 % CI | % (n/N) | 95 % CI | |||
HC2 | FTA | 22.8 | 91.7 (11/12) | 76.1 ~ 100.0 | 79.5 (283/356) | 75.3 ~ 83.7 | 13.1 (11/84) | 5.9 ~ 20.3 | 99.6 (283/284) | 98.9 ~ 100.0 |
Liquid | 30.4 | 91.7 (11/12) | 76.1 ~ 100.0 | 71.6 (255/356) | 66.9 ~ 76.3 | 9.8 (11/112) | 4.3 ~ 15.3 | 99.6 (255/256) | 98.8 ~ 100.0 | |
careHPV™ | FTA | 23.9 | 83.3 (10/12) | 62.2 ~ 100.0 | 78.1 (278/356) | 73.8 ~ 82.4 | 11.4 (10/88) | 4.8 ~ 18 | 99.3 (278/280) | 98.3 ~ 100.0 |
Liquid | 28.8 | 83.3 (10/12) | 62.2 ~ 100.0 | 73.0 (260/356) | 68.4 ~ 77.6 | 9.4 (10/106) | 3.8 ~ 15 | 99.2 (260/262) | 98.1 ~ 100.0 | |
Cobas®4800 | FTA | 39.4 | 91.7 (11/12) | 76.1 ~ 100.0 | 62.4 (222/356) | 57.4 ~ 67.4 | 7.6 (11/145) | 3.3 ~ 11.9 | 99.6 (222/223) | 98.8 ~ 100.0 |
Liquid | 32.1 | 91.7 (11/12) | 76.1 ~ 100.0 | 69.9 (249/356) | 65.1 ~ 74.7 | 9.3 (11/118) | 4.1 ~ 14.5 | 99.6 (249/250) | 98.8 ~ 100.0 | |