From: Prolonged use of human insulin increases breast cancer risk in Taiwanese women with type 2 diabetes
Model | n/N | HR | 95Â % CI | P |
---|---|---|---|---|
Model I | Â | Â | Â | Â |
 Never users of insulin | 4165/345654 | 1.000 |  |  |
 Users of human insulin alone without any OAD | 39/2939 | 1.413 | (1.030-1.940) | 0.0323 |
 OAD plus human insulin < 2 years | 636/88019 | 0.728 | (0.668-0.793) | <0.0001 |
 OAD plus human insulin ≥ 2 years | 430/45421 | 0.983 | (0.882-1.096) | 0.7587 |
Model II | Â | Â | Â | Â |
 Never users of insulin | 4165/345654 | 1.000 |  |  |
 Users of human insulin alone or plus OAD excluding metformin | 82/7827 | 1.127 | (0.904-1.405) | 0.2893 |
 Users of human insulin plus metformin < 2 years | 23/2285 | 0.782 | (0.519-1.178) | 0.2398 |
 Users of human insulin plus metformin ≥ 2 years | 1000/126267 | 0.798 | (0.741-0.859) | <0.0001 |
Model III | Â | Â | Â | Â |
 Never users of insulin | 4165/345654 | 1.000 |  |  |
 Users of human insulin plus without use of statin | 442/51396 | 0.928 | (0.839-1.027) | 0.1484 |
 Users of human insulin plus statin < 2 years | 63/8601 | 0.654 | (0.509-0.840) | 0.0009 |
 Users of human insulin plus statin ≥ 2 years | 600/76382 | 0.789 | (0.718-0.866) | <0.0001 |
Model IV | Â | Â | Â | Â |
 Never users of insulin | 4165/345654 | 1.000 |  |  |
 Users of human insulin plus without use of ACEI/ARB | 223/26367 | 0.822 | (0.716-0.943) | 0.0052 |
 Users of human insulin plus ACEI/ARB < 2 years | 492/69952 | 0.745 | (0.675-0.822) | <0.0001 |
 Users of human insulin plus ACEI/ARB ≥ 2 years | 390/40060 | 1.005 | (0.895-1.128) | 0.9370 |