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Table 2 Univariate and multivariate analyses of overall survival

From: High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases

Variable

Univariate

Multivariate

 

p value

Hazard ratio

95 % CI

p value

Hazard ratio

95 % CI

Age, ≧70 years

0.39

0.7

0.3–1.6

   

Sex, male

0.02

0.4

0.2–0.9

-

-

-

Timing of hepatectomy, synchronous

0.03

2.4

1.0–5.0

-

-

-

Distributution, biloblar

<0.01

3.4

1.5–7.5

-

-

-

Number of tumors, ≧4

<0.01

4.2

1.9–9.4

-

-

-

Diameter of tumors, ≧3

0.28

1.5

0.7–3.1

   

Primary site, rectum

0.22

1.6

0.8–3.4

   

Primary lymph node metastases, yes

0.91

1.0

0.5–2.3

   

Extrahepatic disease, yes

<0.01

4.5

1.9–11

-

-

-

Neoadjuvant chemotherapy, yes

<0.01

3.9

1.7–8.5

-

-

-

CRP, ≧2 mg/L

0.2

2.3

0.6–7.9

   

Alb, <3.5 g/dL

<0.01

6.4

1.6–25

<0.01

14.5

2.2–92

Lymphocytes, <1000

0.55

1.3

0.6–2.9

   

Neutrophils, ≧6000

0.27

2.8

0.5–17

   

CEA, ≧100 ng/mL

<0.01

3.3

1.4–8.0

-

-

-

Peritumoral MCs, high

<0.01

8.6

3.6–20

<0.01

17.3

4.8–62

Peritumoral Mφs, high

0.13

2.0

0.8–5.0

   

Peritumoral mature DCs, high

0.34

1.7

0.6–5.3

   
  1. CI confidence interval, CRP C-reactive protein, Alb albumin, CEA carcinoembryonic antigen, MCs mast cells, Mφs macrophages, DCs dendritic cells