Table 3 Determination of IgA and AgG antibodies against H. pylori in gastric tissue from gastric cancer group by sampling site and cancer stage
From: Gastric cancer progression associated with local humoral immune responses
Immunoglobulin A | |||
Early gastric cancer n (5) | Advanced gastric cancer n (12) | ||
Sampling site | OD Median (IQR) | OD Median (IQR) | p value* |
Antrum | 0.913 (0.578–0.937) | 0.825 (0.689–0.945) | NS |
Corpus | 0.870 (0.688–0.957) | 0.823 (0.735–1.039) | NS |
Fundus | 0.668 (0.668–0.772) | 0.851 (0.717–1.115) | NS |
Angular portion | 0.637 (0.637–0.833) | 0.881 (0.744–1.075) | NS |
p value (predetermined sites) | NS | NS | |
Mid-lesion | 0.811 (0.474–0.827) | 0.273 (0.150–0.632) | NS |
Tumor margin | 0.941 (0.762–1.147) | 0.889 (0.484–0.965) | NS |
At least 2 cm | 1.175 (0.606–1.220) | 0.869 (0.628–1.225) | NS |
At least 5 cm | 0.919 (0.753–0.928) | 0.915 (0.642–1.308) | NS |
p value (tumor sites) | NS | 0.0023 | |
p value (predetermined sites + tumor sites) | NS | 0.0083 | |
Immunoglobulin G | |||
Early gastric cancer n (5) | Advanced gastric cancer n (12) | ||
Sampling site | OD Median (IQR) | OD Median (IQR) | p value* |
Antrum | 0.375 (0.192–0.563) | 0.182 (0.156–0.289) | NS |
Corpus | 0.473 (0.273–0.513) | 0.285 (0.175–0.627) | NS |
Fundus | 0.516 (0.340–0.527) | 0.299 (0.159–0.441) | NS |
Angular portion | 0.258 (0.236–0.550) | 0.222 (0.142–0.348) | NS |
p value (predetermined sites) | NS | NS | |
Mid-lesion | 0.285 (0.281–0.534) | 0.151 (0.103–0.233) | NS |
Tumor margin | 0.508 (0.463–0.565) | 0.221 (0.119–0.348) | NS |
At least 2 cm | 0.631 (0.296–0.926) | 0.212 (0.133–0.501) | NS |
At least 5 cm | 0.439 (0.215–0.558) | 0.188 (0.161–0.372) | NS |
p value (tumor sites) | NS | 0.0097 | |
p value (predetermined sites + tumor sites) | NS | NS | |