Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

Table 4 Correlation between tumor expression of IAPs and caspases and clinicopahological features

	Procaspase-8		Cleaved caspase-8		Procaspase-3		Cleaved caspase-3		Caspase-7		Procaspase-9
	r	p	r	p	r	p	r	p	r	p	r	p
Preoperative serum PSA	0.000	1.000	0.294	0.007*	0.076	0.494	−0.098	0.377	0.185	0.091	0.017	0.881
Pathological T stage	0.216	0.048*	−0.056	0.611	−0.154	0.161	0.160	0.146	−0.023	0.833	−0.072	0.513
Clinical T stage	0.235	0.031*	−0.003	0.979	−0.161	0.144	−0.055	0.617	0.121	0.237	−0.054	0.625
Gleason score	0.118	0.287	−0.006	0.954	0.013	0.904	0.107	0.331	0.289	0.008*	−0.151	0.171
Perineural invasion	0.118	0.285	0.104	0.345	−0.023	0.834	0.027	0.808	0.007	0.951	−0.046	0.680
Node involvement	−0.175	0.110	0.007	0.952	−0.110	0.318	0.147	0.183	0.250	0.022*	0.068	0.539
Positive surgical margins	0.160	0.145	−0.149	0.176	−0.277	0.011*	−0.098	0.377	−0.037	0.738	0.133	0.229
Biochemical progresion	0.015	0.890	−0.126	0.254	−0.362	0.001*	−0.364	0.001*	0.082	0.461	0.002	0.983
Survival	0.163	0.139	0.014	0.898	−0.161	0.142	−0.250	0.022*	−0.202	0.065	−0.133	0.229

Correlations between immunohistochemical variables (according to the stratification shown in Table 2) and preoperative serum PSA, pathological T stage, clinical T stage and Gleason score were evaluated by Spearman’s test (r, correlation coefficient). *p < 0.05. (Note: significant correlations after Bonferroni correction should be those with a p < 0.005)

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