| |
Procaspase-8
|
Cleaved caspase-8
|
Procaspase-3
|
Cleaved caspase-3
|
Caspase-7
|
Procaspase-9
|
|---|
| |
r
|
p
|
r
|
p
|
r
|
p
|
r
|
p
|
r
|
p
|
r
|
p
|
|---|
|
Preoperative serum PSA
|
0.000
|
1.000
|
0.294
|
0.007*
|
0.076
|
0.494
|
−0.098
|
0.377
|
0.185
|
0.091
|
0.017
|
0.881
|
|
Pathological T stage
|
0.216
|
0.048*
|
−0.056
|
0.611
|
−0.154
|
0.161
|
0.160
|
0.146
|
−0.023
|
0.833
|
−0.072
|
0.513
|
|
Clinical T stage
|
0.235
|
0.031*
|
−0.003
|
0.979
|
−0.161
|
0.144
|
−0.055
|
0.617
|
0.121
|
0.237
|
−0.054
|
0.625
|
|
Gleason score
|
0.118
|
0.287
|
−0.006
|
0.954
|
0.013
|
0.904
|
0.107
|
0.331
|
0.289
|
0.008*
|
−0.151
|
0.171
|
|
Perineural invasion
|
0.118
|
0.285
|
0.104
|
0.345
|
−0.023
|
0.834
|
0.027
|
0.808
|
0.007
|
0.951
|
−0.046
|
0.680
|
|
Node involvement
|
−0.175
|
0.110
|
0.007
|
0.952
|
−0.110
|
0.318
|
0.147
|
0.183
|
0.250
|
0.022*
|
0.068
|
0.539
|
|
Positive surgical margins
|
0.160
|
0.145
|
−0.149
|
0.176
|
−0.277
|
0.011*
|
−0.098
|
0.377
|
−0.037
|
0.738
|
0.133
|
0.229
|
|
Biochemical progresion
|
0.015
|
0.890
|
−0.126
|
0.254
|
−0.362
|
0.001*
|
−0.364
|
0.001*
|
0.082
|
0.461
|
0.002
|
0.983
|
|
Survival
|
0.163
|
0.139
|
0.014
|
0.898
|
−0.161
|
0.142
|
−0.250
|
0.022*
|
−0.202
|
0.065
|
−0.133
|
0.229
|
- Correlations between immunohistochemical variables (according to the stratification shown in Table 2) and preoperative serum PSA, pathological T stage, clinical T stage and Gleason score were evaluated by Spearman’s test (r, correlation coefficient). *p < 0.05. (Note: significant correlations after Bonferroni correction should be those with a p < 0.005)
