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Table 3 IC50 values obtained for N-Br and N-I treatment of different tumor cells and non-tumorigenic cell lineages

From: Benzofuroxan derivatives N-Br and N-I induce intrinsic apoptosis in melanoma cells by regulating AKT/BIM signaling and display anti metastatic activity in vivo

 

IC50 (μM)

Cell lineage

N-Br

N-I

B16F10-Nex2

16.5 ± 0.9

12.0 ± 0.4

HCT

32.2 ± 6.6

21.4 ± 3.8

U87

49.1 ± 5.5

58.7 ± 1.4

HeLa

21.7 ± 6.4

25.6 ± 7.2

CT26

34.7 ± 5.8

26.4 ± 4.1

Ovcar-3

18.1 ± 1.9

17.3 ± 3.0

Fibro T75

27.7 ± 2.1

20.6 ± 1.6

GM637

9.4 ± 2.0

9.1 ± 4.3

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BMC Cancer

ISSN: 1471-2407

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