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Table 3 IC50 values obtained for N-Br and N-I treatment of different tumor cells and non-tumorigenic cell lineages

From: Benzofuroxan derivatives N-Br and N-I induce intrinsic apoptosis in melanoma cells by regulating AKT/BIM signaling and display anti metastatic activity in vivo

  IC50 (μM)
Cell lineage N-Br N-I
B16F10-Nex2 16.5 ± 0.9 12.0 ± 0.4
HCT 32.2 ± 6.6 21.4 ± 3.8
U87 49.1 ± 5.5 58.7 ± 1.4
HeLa 21.7 ± 6.4 25.6 ± 7.2
CT26 34.7 ± 5.8 26.4 ± 4.1
Ovcar-3 18.1 ± 1.9 17.3 ± 3.0
Fibro T75 27.7 ± 2.1 20.6 ± 1.6
GM637 9.4 ± 2.0 9.1 ± 4.3