Fig. 3From: Benzofuroxan derivatives N-Br and N-I induce intrinsic apoptosis in melanoma cells by regulating AKT/BIM signaling and display anti metastatic activity in vivoApoptotic effects of N-Br and N-I in B16F10-Nex2 cells (a) Phosphatidylserine translocation determined by annexin V. b Caspase-3 activation determined by colorimetric assay (*p < 0,05). c Evaluation of caspase-9 and cleavage of PARP induced by the benzofuroxan derivativesBack to article page