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Table 1 Main characteristics of the studies included in this meta-analysis

From: The importance of extranodal extension in penile cancer: a meta-analysis

First author

Year

Country

Recruitment period

Study design

Age (median)

Follow-up (mean/median)

No. pts

No. ENE Pts (%)

No. PLND Pts (%)

No. PLNM Pts (%)

Outcomes measured

NOS score

Djajadiningrat [13]

2014

Netherlands

1956–2012

retrospective

64

65 m

300

134(45)

NA

58(19)

CSS: Multivariable HR reported

8

Lughczznni (a) [18]

2013

Italy

2000–2012

retrospective

61

26 m

81

40(49)

56(69)

NA

CSS: Multivariable HR reported

8

Pandey [14]

2006

India

1987–1998

retrospective

45

NA

102

54(53)

NA

21(22)

OS: Multivariable HR reported

8

Svatek [17]

2009

USA

1979–2007

retrospective

61

24 m

45

11(24)

33(73)

NA

CSS: Multivariable HR reported

8

Sun [15]

2014

Canada

1994–2010

retrospective

65

43 m

155

71(46)

NA

31(7.1)

CSS: Curve estimated HR

7

Zhu(a) [27]

2011

China

1990–2008

retrospective

48

53 m

60

16(27)

29(48)

8(13)

RFS: Curve estimated HR

7

Liu [16]

2013

China

1998–2011

retrospective

51

42 m

76

29(38)

42(55)

33(43)

OS: Multivariable HR reported

6

PLNM: Multivariable OR reported

Zhu(b) [21]

2008

China

1990–200

retrospective

NA

38 m

33a

5(15)

16(48)

12(36)

PLNM:univariateOR calculated

7

Lont [20]

2007

Netherlands

1956–2011

retrospective

63

85 m

102

NA

53(52)

25(25)

PLNM: Multivariable OR reported

8

Lughczznni (b) [28]

2014

Italy

1985–2012

retrospective

63

51 m

188b

98(52)

160(85)

51(27)

PLNM: Multivariable OR reported

8

  1. NA not available, ENE extranodal extension, CSS cancer specific survival, OS overall survival, RFS recurrence free survival, PLND pelvic lymph node dissection, PLNM pelvic lymph node metastasis, OR odds ratio, HR hazard ratio, NOS Newcastle-Ottawa Scale
  2. a30 patients and 33 groin basins;b142 patients and 188 groin basins