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Fig. 5 | BMC Cancer

Fig. 5

From: The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype

Fig. 5

Assessment of the estrogen pretreated progesterone transcriptome reveals functionally associated clusters, and results in the ZR-75-1 cells switching from a Luminal A to a Basal subtype. a Cluster analysis reveals 6 functionally associated clusters. b PAM50 analysis utilising the microarray data using ZR-75-1 cells treated with 10nM estrogen for 72 h followed by vehicle treatment for 16 h (E2p + VC), or with 4, 8 or 16 h of 10nM progesterone treatment. Colours represent the closest centroid for each sample type. c Unscaled recurrence score (uRS) from Oncotype DX™ calculated from microarray data using the method described in [59]

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BMC Cancer

ISSN: 1471-2407

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