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Table 3 Selected gene sets differentiated between pilocytic astrocytomas of variable clinical features

From: Transcriptional profiles of pilocytic astrocytoma are related to their three different locations, but not to radiological tumor features

Broad GeneSets Number of genes LS KS GSA
p-value p-value p-value
KONDO_PROSTATE_CANCER_HCP_WITH_H3K27ME3 100 0.00001 0.00001 <0.005
LI_CISPLATIN_RESISTANCE_UP 66 0.00001 0.00019 <0.005
REACTOME_ACTIVATED_TLR4_SIGNALLING 25 0.00001 0.00001 <0.005
REACTOME_TOLL_LIKE_RECEPTOR_4_CASCADE 28 0.00001 0.00001 <0.005
SHARMA_PILOCYTIC_ASTROCYTOMA_LOCATION_DN 7 0.00001 0.00001 <0.005
SHARMA_PILOCYTIC_ASTROCYTOMA_LOCATION_UP 31 0.00001 0.00001 <0.005
WATANABE_COLON_CANCER_MSI_VS_MSS_DN 96 0.00001 0.00041 <0.005
ZHAN_MULTIPLE_MYELOMA_PR_DN 69 0.00001 0.00001 <0.005
BIOCARTA_DC_PATHWAY 13 0.00023 0.00079 <0.005
CGGTGTG, MIR-220 8 0.00001 0.09215 <0.005
V$GNCF_01 93 0.00002 0.00239 0.04
GGGATGC, MIR-324-5P 72 0.00003 0.01085 <0.005
CCATCCA, MIR-432 64 0.00006 0.00044 0.015
V$POU3F2_01 94 0.00006 0.02333 0.025
CCANNAGRKGGC_UNKNOWN 89 0.00017 0.00001 0.035
V$CDPCR3_01 39 0.00028 0.02874 0.065
CCCACAT,MIR-299-3P 72 0.00034 0.08243 0.07
V$MYOGNF1_01 57 0.00045 0.01553 0.045
CTGYNNCTYTAA_UNKNOWN 73 0.00055 0.00747 0.09
GTACAGG, MIR-486 72 0.00056 0.00176 0.01
V$PAX8_01 49 0.00058 0.0018 <0.005
V$AHR_01 86 0.00068 0.05371 0.16
CCAATNNSNNNGCG_UNKNOWN 65 0.00407 0.22226 <0.005
AGTCTTA, MIR-499 99 0.02398 0.00033 0.22
V$MEF2_04 24 0.03997 0.01638 <0.005
  1. Three independent tests: LS, KS permutation test, and Efron-Tibshirani’s GSA maxmean test were applied to select significantly affected gene classes