| | |
HPV (–)
|
HPV (+)
|
HPV (-)
|
HPV (+)
| |
|---|
|
Characteristic
| |
N
|
(%) among HPV(-)
|
N
|
(%) among HPV(+)
|
Mean (SD)
|
Mean (SD)
|
p-value
|
|---|
|
Age at Dx (years)
| |
211
| |
135
| |
61.4 (12.3)
|
57.0 (9.6)
|
0.0002
|
|
Gender
|
Male
|
139
|
66 %
|
120
|
89 %
| | |
<0.0001
|
| |
Female
|
72
|
34 %
|
15
|
11 %
| | | |
|
Cancer Site
|
Larynx/Glottic
|
72
|
34 %
|
11
|
8 %
| | |
<0.0001
|
| |
Oral Cavity
|
110
|
52 %
|
16
|
12 %
| | | |
| |
Oropharynx
|
20
|
9 %
|
105
|
78 %
| | | |
| |
Hypopharynx
|
9
|
4 %
|
3
|
2 %
| | | |
|
Cancer Stage
|
I/Cis
|
36
|
17 %
|
11
|
8 %
| | |
<0.0001
|
| |
II
|
28
|
13 %
|
7
|
5 %
| | | |
| |
III
|
39
|
18 %
|
13
|
10 %
| | | |
| |
IV
|
108
|
51 %
|
104
|
77 %
| | | |
|
Comorbidities (ACE)
|
None
|
41
|
19 %
|
50
|
37 %
| | |
0.001
|
| |
Mild
|
99
|
47 %
|
59
|
44 %
| | | |
| |
Moderate
|
50
|
24 %
|
20
|
15 %
| | | |
| |
Severe
|
21
|
10 %
|
6
|
4 %
| | | |
|
Tobacco Use
|
Current (within past 12 months)
|
102
|
48 %
|
43
|
32 %
| | |
0.001
|
| |
Former (quit > 12 months)
|
75
|
36 %
|
50
|
37 %
| | | |
| |
Never
|
34
|
16 %
|
42
|
31 %
| | | |
|
Pack Years, n = 257
|
(cigs only)
| | | | |
38.4 (25.6)
|
29.9 (28.8)
|
0.02
|
|
Pack Years, n = 264
|
(cigs, cigars, pipe)
| | | | |
41.8 (34.5)
|
29.6 (29.4)
|
0.005
|
|
Alcohol Use, n = 244
|
Current (within past 12 months)
|
63
|
30 %
|
27
|
20 %
| | |
0.01
|
| |
Former (quit > 12 months)
|
126
|
60 %
|
101
|
75 %
| | | |
| |
Never
|
22
|
10 %
|
7
|
5 %
| | | |
|
Treatment, n = 335
|
Surg alone
|
53
|
26 %
|
14
|
11 %
| | |
<0.0001
|
| |
Rad alone
|
23
|
11 %
|
11
|
8 %
| | | |
| |
Surg + Rad
|
30
|
15 %
|
4
|
3 %
| | | |
| |
Rad + Chemo
|
45
|
22 %
|
93
|
70 %
| | | |
| |
Surg + Rad + Chemo
|
29
|
14 %
|
10
|
8 %
| | | |
| |
No Treatment prior to death
|
22
|
11 %
|
1
|
1 %
| | | |
|
Post Treatment Status
|
Free of Disease
|
186
|
88 %
|
131
|
97 %
| | |
0.004
|
| |
Persistent Disease
|
25
|
12 %
|
4
|
3 %
| | | |
|
KM estimate 2 year RPFT
| | |
69 %
| |
84 %
| | |
0.001
|
|
KM estimate 2 year OST
| | |
71 %
| |
91 %
| | |
<0.0001
|
- -Percentages will not add to 100 % horizontally. % presented is proportion of clinical or epidemiological subgroup among HPV status category. -p-values calculated by Wilcoxon-rank tests for continuous variables and Kruskal-Wallis tests for categorical variables. Log-rank test used for KM analysis
