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Table 2 Patient clinical and epidemiological characteristics by HPV status, N = 346

From: NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas

   HPV (–) HPV (+) HPV (-) HPV (+)  
Characteristic   N (%) among HPV(-) N (%) among HPV(+) Mean (SD) Mean (SD) p-value
Age at Dx (years)   211   135   61.4 (12.3) 57.0 (9.6) 0.0002
Gender Male 139 66 % 120 89 %    <0.0001
  Female 72 34 % 15 11 %    
Cancer Site Larynx/Glottic 72 34 % 11 8 %    <0.0001
  Oral Cavity 110 52 % 16 12 %    
  Oropharynx 20 9 % 105 78 %    
  Hypopharynx 9 4 % 3 2 %    
Cancer Stage I/Cis 36 17 % 11 8 %    <0.0001
  II 28 13 % 7 5 %    
  III 39 18 % 13 10 %    
  IV 108 51 % 104 77 %    
Comorbidities (ACE) None 41 19 % 50 37 %    0.001
  Mild 99 47 % 59 44 %    
  Moderate 50 24 % 20 15 %    
  Severe 21 10 % 6 4 %    
Tobacco Use Current (within past 12 months) 102 48 % 43 32 %    0.001
  Former (quit > 12 months) 75 36 % 50 37 %    
  Never 34 16 % 42 31 %    
Pack Years, n = 257 (cigs only)      38.4 (25.6) 29.9 (28.8) 0.02
Pack Years, n = 264 (cigs, cigars, pipe)      41.8 (34.5) 29.6 (29.4) 0.005
Alcohol Use, n = 244 Current (within past 12 months) 63 30 % 27 20 %    0.01
  Former (quit > 12 months) 126 60 % 101 75 %    
  Never 22 10 % 7 5 %    
Treatment, n = 335 Surg alone 53 26 % 14 11 %    <0.0001
  Rad alone 23 11 % 11 8 %    
  Surg + Rad 30 15 % 4 3 %    
  Rad + Chemo 45 22 % 93 70 %    
  Surg + Rad + Chemo 29 14 % 10 8 %    
  No Treatment prior to death 22 11 % 1 1 %    
Post Treatment Status Free of Disease 186 88 % 131 97 %    0.004
  Persistent Disease 25 12 % 4 3 %    
KM estimate 2 year RPFT    69 %   84 %    0.001
KM estimate 2 year OST    71 %   91 %    <0.0001
  1. -Percentages will not add to 100 % horizontally. % presented is proportion of clinical or epidemiological subgroup among HPV status category. -p-values calculated by Wilcoxon-rank tests for continuous variables and Kruskal-Wallis tests for categorical variables. Log-rank test used for KM analysis