NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas

BMC Cancer

Table 1 Patient clinical and epidemiological characteristics, N = 346

Characteristic		N	(%)	Mean (std), range
Age at Dx (years)				59.7 (11.5), 25-93
Gender	Male	259	75 %
	Female	87	25 %
Cancer Site	Larynx/Glottic	83	24 %
	Oral Cavity	126	36 %
	Oropharynx	125	36 %
	Hypopharynx	12	3 %
Cancer Stage	I/Cis	47	14 %
	II	35	10 %
	III	52	15 %
	IV	212	61 %
Comorbidities (ACE)	None	91	26 %
	Mild	158	46 %
	Moderate	70	20 %
	Severe	27	8 %
HPV status	Positive	135	39 %
	Negative	211	61 %
Tobacco Use	Current (within past 12 months)	145	42 %
	Former (quit > 12 months)	125	36 %
	Never	76	22 %
Pack Years, n = 257	(cigs only)			35.6 (30.0), 0.1-171.0
Pack Years, n = 264	(sum of cigs, cigars, pipe)			37.7 (33.3), 0.07-242.9
Alcohol Use, n = 244	Never	29	8 %
	Former (quit >12 months)	227	66 %
	Current (within past 12 months)	90	26 %
Treatment, n = 335	Surgery alone	67	20 %
	Radiation alone	34	10 %
	Surgery + Radiation	34	10 %
	Radiation + Chemotherapy	138	41 %
	Surgery + Radiation + Chemotherapy	39	12 %
	No Treatment prior to death	23	7 %
Persistent Disease^a		29	8 %
Median Follow-up for Survival		27 months
Median Follow-up for Recurrence/Persistence		24 months
Recurrence/Persistence^b		81
Death		78
KM estimate 2 year RPFT^c			75 %
KM estimate 2 year OST^d			79 %

^aDisease considered persistent if patient never became disease free. ^bRecurrence of the HNSCC in the primary, regional and/or a distant location. Persistent patients whose disease never cleared after treatment are included and considered recurrent with a recurrence time = 1 day. ^cRPFT Recurrence/Persistent Free Time defined as time from diagnosis to recurrence event or end of follow-up. End of follow-up is the last date where patient was reviewed for recurrence. Patients whose disease never cleared after treatment are considered recurrent with a recurrence time = 1 day. ^dOST Overall Survival Time. Death from any cause considered an event. Overall survival time defined from date of diagnosis by UM physician

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