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Table 1 Patient clinical and epidemiological characteristics, N = 346

From: NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas

Characteristic   N (%) Mean (std), range
Age at Dx (years)     59.7 (11.5), 25-93
Gender Male 259 75 %  
  Female 87 25 %  
Cancer Site Larynx/Glottic 83 24 %  
  Oral Cavity 126 36 %  
  Oropharynx 125 36 %  
  Hypopharynx 12 3 %  
Cancer Stage I/Cis 47 14 %  
  II 35 10 %  
  III 52 15 %  
  IV 212 61 %  
Comorbidities (ACE) None 91 26 %  
  Mild 158 46 %  
  Moderate 70 20 %  
  Severe 27 8 %  
HPV status Positive 135 39 %  
  Negative 211 61 %  
Tobacco Use Current (within past 12 months) 145 42 %  
  Former (quit > 12 months) 125 36 %  
  Never 76 22 %  
Pack Years, n = 257 (cigs only)    35.6 (30.0), 0.1-171.0
Pack Years, n = 264 (sum of cigs, cigars, pipe)    37.7 (33.3), 0.07-242.9
Alcohol Use, n = 244 Never 29 8 %  
  Former (quit >12 months) 227 66 %  
  Current (within past 12 months) 90 26 %  
Treatment, n = 335 Surgery alone 67 20 %  
  Radiation alone 34 10 %  
  Surgery + Radiation 34 10 %  
  Radiation + Chemotherapy 138 41 %  
  Surgery + Radiation + Chemotherapy 39 12 %  
  No Treatment prior to death 23 7 %  
Persistent Diseasea   29 8 %  
Median Follow-up for Survival   27 months   
Median Follow-up for Recurrence/Persistence   24 months   
Recurrence/Persistenceb   81   
Death   78   
KM estimate 2 year RPFTc    75 %  
KM estimate 2 year OSTd    79 %  
  1. aDisease considered persistent if patient never became disease free. bRecurrence of the HNSCC in the primary, regional and/or a distant location. Persistent patients whose disease never cleared after treatment are included and considered recurrent with a recurrence time = 1 day. cRPFT Recurrence/Persistent Free Time defined as time from diagnosis to recurrence event or end of follow-up. End of follow-up is the last date where patient was reviewed for recurrence. Patients whose disease never cleared after treatment are considered recurrent with a recurrence time = 1 day. dOST Overall Survival Time. Death from any cause considered an event. Overall survival time defined from date of diagnosis by UM physician