Table 3 Univariate and multivariate analyses of clinicopathologic variables affecting RFS in patients with A: stage II CRC and B: stage III CRC

Variables

No. Patients

Hazard ratio (95 % CI)

p value

Hazard ratio (95 % CI)

p value

 Age

< 70 years

53

2.984 (1.249–7.130)

0.014

2.798 (1.168–6.702)

0.021

≥ 70 years

34

 Gender

male

53

0.506 (0.198–1.294)

0.155

female

34

 Histology (TNM 7th)

G1

36

1.041 (0.445–2.438)

0.926

G2, G3

51

 Tumor location

colon

57

1.723 (0.744–3.989)

0.204

rectum

30

 Depth of tumor invasion (TNM 7th)

T1-3

62

1.269 (0.517–3.115)

0.603

T4

25

 Lymphatic invasion

(-)

36

1.292 (0.541–3.083)

0.564

(+)

51

 Venous invasion

(-)

11

1.550 (0.362–6.635)

0.555

(+)

76

 Examined lymph nodes

< 12

21

0.820 (0.321–2.097)

0.679

≥ 12

66

 CEA

< 5 ng/ml

62

1.153 (0.450–2.954)

0.767

≥ 5 ng/ml

25

 TNIK expression

low

55

2.511 (1.073–5.877)

0.034

2.323 (0.990–5.452)

0.053

high

32

Variables

No. Patients

Hazard ratio (95 % CI)

p value

Hazard ratio (95 % CI)

p value

 Age

< 70 years

60

1.032 (0.536–1.988)

0.925

≥ 70 years

25

 Gender

male

60

0.681 (0.334–1.385)

0.289

female

25

 Histology (TNM 7th)

G1

24

1.838 (0.878–3.846)

0.106

G2, G3

61

 Tumor location

colon

48

1.540 (0.839–2.824)

0.163

rectum

37

 Depth of tumor invasion (TNM 7th)

T1-3

43

1.308

0.388

T4

42

 Lymphatic invasion

(-)

4

0.706

(+)

81

 Venous invasion

(-)

3

0.570

(+)

82

 Lymph node metastasis (TNM 7th)

N1

48

0.194

N2

37

 CEA

< 5 ng/ml

47

1.918 (1.042–3.530)

0.036

1.678 (0.903–3.120)

0.102

≥ 5 ng/ml

38

 TNIK expression

low

48

2.345 (1.256–4.378)

0.007

2.141 (1.136–4.038)

0.019

high

37