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Table 3 Univariate and multivariate analyses of clinicopathologic variables affecting RFS in patients with A: stage II CRC and B: stage III CRC

From: Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer

Variables   No. Patients Univariate analysis Multivariate analysis
Hazard ratio (95 % CI) p value Hazard ratio (95 % CI) p value
stage II
 Age < 70 years 53 2.984 (1.249–7.130) 0.014 2.798 (1.168–6.702) 0.021
≥ 70 years 34
 Gender male 53 0.506 (0.198–1.294) 0.155   
female 34
 Histology (TNM 7th) G1 36 1.041 (0.445–2.438) 0.926   
G2, G3 51
 Tumor location colon 57 1.723 (0.744–3.989) 0.204   
rectum 30
 Depth of tumor invasion (TNM 7th) T1-3 62 1.269 (0.517–3.115) 0.603   
T4 25
 Lymphatic invasion (-) 36 1.292 (0.541–3.083) 0.564   
(+) 51
 Venous invasion (-) 11 1.550 (0.362–6.635) 0.555   
(+) 76
 Examined lymph nodes < 12 21 0.820 (0.321–2.097) 0.679   
≥ 12 66
 CEA < 5 ng/ml 62 1.153 (0.450–2.954) 0.767   
≥ 5 ng/ml 25
 TNIK expression low 55 2.511 (1.073–5.877) 0.034 2.323 (0.990–5.452) 0.053
high 32
Variables   No. Patients Univariate analysis Multivariate analysis
Hazard ratio (95 % CI) p value Hazard ratio (95 % CI) p value
stage III
 Age < 70 years 60 1.032 (0.536–1.988) 0.925   
≥ 70 years 25
 Gender male 60 0.681 (0.334–1.385) 0.289   
female 25
 Histology (TNM 7th) G1 24 1.838 (0.878–3.846) 0.106   
G2, G3 61
 Tumor location colon 48 1.540 (0.839–2.824) 0.163   
rectum 37
 Depth of tumor invasion (TNM 7th) T1-3 43 1.308 0.388   
T4 42
 Lymphatic invasion (-) 4   0.706   
(+) 81
 Venous invasion (-) 3   0.570   
(+) 82
 Lymph node metastasis (TNM 7th) N1 48   0.194   
N2 37
 CEA < 5 ng/ml 47 1.918 (1.042–3.530) 0.036 1.678 (0.903–3.120) 0.102
≥ 5 ng/ml 38
 TNIK expression low 48 2.345 (1.256–4.378) 0.007 2.141 (1.136–4.038) 0.019
high 37