Fig. 1

Expression of p38 MAPK and p-p38 MAPK in patients with DLBCL Tissue microarray-based immunohistochemical analyses of p38 MAPK and p-p38 MAPK in representative tumor biopsies from DLBCL patients. DLBCL array cores showing over-expression of p38 MAPK (a), high expression of p-p38 MAPK (b) and another DLBCL tissue array core shows no or low expression of p38 MAPK (c). 40X objective on an Olympus BX 51 microscope (Olympus America, Center Valley, PA, USA), (Left) and 100X aperture view of the same tissue (Right). Of the 80 DLBCL biopsies analyzed, 82 % were positive for p38 and only 30 % were positive for p-p38 MAPK (d). The percentages were calculated based on the threshold used for ≤ 30 % expressed cells considered negative and ≥ 30 % stained cells were considered positive as descried in methods