Table 2 Association of GATA4 promoter methylation with clinico-pathological characteristics in 105 pediatric AML samples
Clinical variables | No. of patients | GATA4 methylation (n) | P | |
|---|---|---|---|---|
Negative | Positive | |||
Sex | ||||
 Male | 42 | 21 | 21 | 0.297 |
 Female | 63 | 25 | 38 |  |
Age (years) | ||||
  < 6 | 60 | 28 | 32 | 0.496 |
  ≥ 6 | 45 | 18 | 27 |  |
Leukocyte (/μl) | ||||
  > 10,000 | 61 | 32 | 29 | 0.035 |
  ≤ 10,000 | 44 | 14 | 30 |  |
FAB | ||||
 M1–M6 | 93 | 38 | 55 | 0.090 |
 M7 | 12 | 8 | 4 |  |
Cytogenetics | ||||
 Favorable | 50 | 16 | 34 | 0.062 |
 Intermediate | 27 | 14 | 13 |  |
 Unfavorable | 28 | 16 | 12 |  |
MRD | ||||
  < 0.25 % | 49 | 16 | 33 | 0.031 |
  ≥ 0.25 % | 56 | 30 | 26 |  |