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Table 2 Association of GATA4 promoter methylation with clinico-pathological characteristics in 105 pediatric AML samples

From: Hypermethylation of the GATA binding protein 4 (GATA4) promoter in Chinese pediatric acute myeloid leukemia

Clinical variables No. of patients GATA4 methylation (n) P
Negative Positive
Sex
 Male 42 21 21 0.297
 Female 63 25 38  
Age (years)
  < 6 60 28 32 0.496
  ≥ 6 45 18 27  
Leukocyte (/μl)
  > 10,000 61 32 29 0.035
  ≤ 10,000 44 14 30  
FAB
 M1–M6 93 38 55 0.090
 M7 12 8 4  
Cytogenetics
 Favorable 50 16 34 0.062
 Intermediate 27 14 13  
 Unfavorable 28 16 12  
MRD
  < 0.25 % 49 16 33 0.031
  ≥ 0.25 % 56 30 26