Table 3 Toxicities in Level-1 cohort
Toxicity | G1, % | G2, % | G3, % | G4, % |
|---|---|---|---|---|
Hematologic | ||||
Neutropenia | 8 | 8 | 25 | 50 |
Leukopenia | 17 | 25 | 50 | 8 |
Anemia | 58 | 8 | 8 | 0 |
Thrombocytopenia | 25 | 8 | 0 | 0 |
Nonhematologic | ||||
AST increased | 17 | 0 | 0 | 0 |
ALT increased | 17 | 0 | 8 | 0 |
Anorexia | 25 | 42 | 8 | 0 |
Nausea | 42 | 8 | 8 | 0 |
Diarrhea | 17 | 17 | 8 | 0 |
Vomiting | 8 | 0 | 8 | 0 |
Stomatitis | 25 | 17 | 0 | 0 |
Constipation | 58 | 8 | 0 | 0 |
Fatigue | 42 | 8 | 0 | 0 |
Hypertension | 8 | 8 | 0 | 0 |
Peripheral neuropathy | 8 | 8 | 0 | 0 |
Weight loss | 17 | 0 | 0 | 0 |
Arthralgia | 8 | 0 | 0 | 0 |
Febrile neutropenia | - | - | 8 | 0 |
Intracranial hemorrhage | 0 | 0 | 8 | 0 |