Table 2 Toxicities in Level 0 cohort
Toxicity | G1, % | G2, % | G3, % | G4, % |
|---|---|---|---|---|
Hematologic | ||||
Neutropenia | 0 | 0 | 11 | 89 |
Leukopenia | 0 | 11 | 56 | 33 |
Anemia | 56 | 22 | 0 | 0 |
Thrombocytopenia | 56 | 11 | 0 | 0 |
Nonhematologic | ||||
AST increased | 33 | 0 | 11 | 0 |
ALT increased | 33 | 0 | 11 | 0 |
Anorexia | 11 | 33 | 22 | 0 |
Stomatitis | 11 | 22 | 11 | 0 |
Nausea | 11 | 33 | 0 | 0 |
Diarrhea | 22 | 22 | 0 | 0 |
Vomiting | 22 | 11 | 0 | 0 |
Allergic reaction | 22 | 11 | 0 | 0 |
Hypertension | 0 | 11 | 0 | 0 |
Dyspnea | 0 | 11 | 0 | 0 |
Peripheral neuropathy | 44 | 0 | 0 | 0 |
Constipation | 33 | 0 | 0 | 0 |
Edema limbs | 22 | 0 | 0 | 0 |
Weight loss | 11 | 0 | 0 | 0 |
Febrile neutropenia | - | - | 11 | 0 |
Infection | 0 | 0 | 11 | 0 |
Sepsis | - | - | - | 22 |
Hypoxia | - | 0 | 11 | 0 |