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Table 3 Rates of persistence/recurrence in patients with positive margin published in literature

From: Factors that influence persistence or recurrence of high-grade squamous intraepithelial lesion with positive margins after the loop electrosurgical excision procedure: a retrospective study

Author Year Total case No. Case inclusion criteria Follow-up period (mean) No. of cases with positive margin and its definition Definition of Persistence/Recurrence Rate of Persistence /Recurrence in cases with positive margin Predict factor of Persistence/Recurrencea
Menghan Z Current study 238 HSIL with HSIL margin 25 months 238 (the presence of HSIL in the margin) Histolopathological confirmed HSIL 11.3 % (27/238) Age and diameter of specimen . in univariate analysis. Age ≥35 was an independent factor
Verguts J [24] 2006 72 CIN 2 or worse 24 months 14 (the presence of CIN presence of > CIN2, biopsy confirmed 14.2 % (2/14) Persistence of HR-HPV DNAa
Sun X [25] 2009 207 CIN 3 not mentioned 10 (the presence of CIN 1 or worse)b pathologic findings of CIN3 50 % (5/10)b Cytological grade, depth of conization, parity and multi-quadrants of CIN 3 in punch biopsy were related to increased risk for positive margin a
Leguevaque P [7] 2010 352 CIN 2,3 73 months 71 (definition not mentioned) Pap smear or biopsy confirmed evidence of CIN of any grade (1,2,3) 25.3 % (18/71) a positive HR-HPV test at 6 months postoperatively,positive endocervical margins,positive pre-treatment HPV typinga
Baloglu A [11] 2010 42 CIN 2,3 8.6 months 5 (the presence of CIN 1,2,3) pathology finding of CIN 1 or CIN 2,3 60 % (3/5) surgical margin positivitya
Kliemann L M [14] 2012 97 CIN 2,3 160 days 39 (the presence of CIN 2,3) pathology findings of CIN 2,3 46.3 % (18/39) positive margin, cone height, tumor sizea
Serati M [26] 2012 282 CIN 1,2,3 26.7 months 21 [the presence of CIN3 was close to (≤1 mm) or involved the margin] colposcopically directed biopsy proved CIN 3 38.1 %(8/21) the surgical margin statusa
  1. aThe predictive factors were analyzed based on the whole case sample, not the particular subgroup of cases with positive margins
  2. bAuthors observed residual CIN in 67 of 207 patients who received hysterectomy, but not including those who received other follow-ups