Table 3 Rates of persistence/recurrence in patients with positive margin published in literature
Author | Year | Total case No. | Case inclusion criteria | Follow-up period (mean) | No. of cases with positive margin and its definition | Definition of Persistence/Recurrence | Rate of Persistence /Recurrence in cases with positive margin | Predict factor of Persistence/Recurrencea |
|---|---|---|---|---|---|---|---|---|
Menghan Z | Current study | 238 | HSIL with HSIL margin | 25 months | 238 (the presence of HSIL in the margin) | Histolopathological confirmed HSIL | 11.3 % (27/238) | Age and diameter of specimen . in univariate analysis. Age ≥35 was an independent factor |
Verguts J [24] | 2006 | 72 | CIN 2 or worse | 24 months | 14 (the presence of CIN | presence of > CIN2, biopsy confirmed | 14.2 % (2/14) | Persistence of HR-HPV DNAa |
Sun X [25] | 2009 | 207 | CIN 3 | not mentioned | 10 (the presence of CIN 1 or worse)b | pathologic findings of CIN3 | 50 % (5/10)b | Cytological grade, depth of conization, parity and multi-quadrants of CIN 3 in punch biopsy were related to increased risk for positive margin a |
Leguevaque P [7] | 2010 | 352 | CIN 2,3 | 73 months | 71 (definition not mentioned) | Pap smear or biopsy confirmed evidence of CIN of any grade (1,2,3) | 25.3 % (18/71) | a positive HR-HPV test at 6 months postoperatively,positive endocervical margins,positive pre-treatment HPV typinga |
Baloglu A [11] | 2010 | 42 | CIN 2,3 | 8.6 months | 5 (the presence of CIN 1,2,3) | pathology finding of CIN 1 or CIN 2,3 | 60 % (3/5) | surgical margin positivitya |
Kliemann L M [14] | 2012 | 97 | CIN 2,3 | 160 days | 39 (the presence of CIN 2,3) | pathology findings of CIN 2,3 | 46.3 % (18/39) | positive margin, cone height, tumor sizea |
Serati M [26] | 2012 | 282 | CIN 1,2,3 | 26.7 months | 21 [the presence of CIN3 was close to (≤1 mm) or involved the margin] | colposcopically directed biopsy proved CIN 3 | 38.1 %(8/21) | the surgical margin statusa |