Fig. 2

In situ BRCA1 expression in TNBC tumors. a Proximity ligation assay showing a representative BRCA1 protein expression across the tumor. Two different subzones were magnified to illustrate high and faint expression. b In situ hybridization assay showing BRCA1 mRNA expression across the same tumor and subzones used for protein detection. In both cases, high heterogeneity of the localization of expression is observed. c. Cox univariate regression and correlation analyses of BRCA1 expression relative to patient clinicopathological features. No relationship of BRCA1 expression with patient outcome was observed