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Table 1 In- and exclusion criteria

From: Colorectal liver metastatic disease: efficacy of irreversible electroporation—a single-arm phase II clinical trial (COLDFIRE-2 trial)

Inclusion criteria

Exclusion criteria

Histologic proof of primary colorectal tumor

Ventricular cardiac arrhythmias

Radiologic proof of colorectal liver metastasis, unsuitable for resection and thermal ablation due to vicinity to vascular or ductal structures

Congestive heart failure, NYHA Class ≥ 3

18F FDG-PET avidity of target lesion and visible on ceCT

Active coronary artery disease

Lesion size ≤ 3.5 cm

History of epilepsy

Adequate bone marrow, liver and renal function

Any implanted stimulation device

ASA-classification 0–3

Chemotherapy <6 weeks prior to treatment