Cost-effectiveness simulation and analysis of colorectal cancer screening in Hong Kong Chinese population: comparison amongst colonoscopy, guaiac and immunologic fecal occult blood testing

Table 3 Optimal strategy according to the Ceiling Ratio in Base-case and Multivariate Scenarios

	Optimal Strategy
Ceiling Ratio	No Screening	Biennial G-FOBT	Annual G-FOBT	Colonoscopy every 10 years	Biennial I-FOBT	Annual I-FOBT
In term of LYs
Base-case scenario
[0, 19,838]		Extended Dominance	Dominance	Dominance	(19,838, 23,742]	(23,742, +∞)
Non-discounted Scenario (Discount Rate = 0 %)
[0, 14,681]		Extended Dominance	Dominance	Dominance	(14,681, 15,856]	(15,856, +∞)
In term of QALYs
Base-case scenario
[0, 2976]		Extended Dominance	Dominance	Dominance	(2976, 4087]	(4087, +∞)
Non-discounted Scenario (Discount Rate = 0 %)
[0, 2510]		Extended Dominance	Dominance	Dominance	(2510, 3294]	(3294, +∞)
Ramsey’s Utility Set Scenario (Cancer free = 1.00; S1/S2 = 0.90; S3 = 0.80; S4 = 0.76)
[0, 12,294]		Extended Dominance	Dominance	Dominance	(12,294, 15,279]	(15,279, +∞)
Ness’s Utility Set Scenario (Cancer free = 0.91; S1 = 0.74; S2 = 0.70; S3 = 0.50; S4 = 0.25)
[0, 9278]		Extended Dominance	Dominance	Dominance	(9278, 11,803]	(11,803, +∞)
Sharp’s Utility Set Scenario (Cancer free = 0.94; S1/S2/S3/S4 = 0.80)
[0, 12,505]		Extended Dominance	Dominance	Dominance	(12,505, 15,460]	(15,460, +∞)

Note: G-FOBT, Guaiac fecal occult blood testing; I-FOBT, immunologic fecal occult blood testing; ∞, infinity

ISSN: 1471-2407