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Table 2 Cell cycle profiles; DNA content was determined by propidium iodide staining of fixed cells and flow cytometric analysis; results are displayed as % of cells (mean ± SEM) on three different donors 24 h after incubation with a 10 nM concentration of PM01215 and PM02781

From: The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo

 

G1 phase

S phase

G2 phase

control

42.3 ± 2.5

14.9 ± 1.4

40.3 ± 1.4

PM01215

61.1 ± 1.7*

3.7 ± 1.0*

34.1 ± 2.4*

PM 02781

61.8 ± 1.0*

3.4 ± 0.8*

33.5 ± 1.7*

  1. *Indicate p values < 0.05