Fig. 5

SPHK1 expression in gastroesophageal cancer patients. a SPHK1 Immunohistochemistry. Representative examples (x400) of strong, moderate and weak tumour SPHK1 staining and proportions of tumours in each category. b SPHK1 immunohistochemistry and overall survival of oesophago-gastric cancer patients treated with either surgery alone or with neoadjuvant chemotherapy prior to surgical resection, grouped negative or weak SPHK1 staining(blue line) versus moderate or strong SPHK1 staining (red line) (Kaplan- Meier survival curve, log rank test)