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Fig. 1 | BMC Cancer

Fig. 1

From: Downregulation of programmed cell death 10 is associated with tumor cell proliferation, hyperangiogenesis and peritumoral edema in human glioblastoma

Fig. 1

Downregulation of PDCD10 was correlated to the activation of Akt in GBM. a Downregulation of PDCD10 mRNA. Real time RT-PCR demonstrated a downregulation of PDCD10 in a malignancy dependent manner in glioma. b-d Downregulation of PDCD10 protein expression was inversely correlated to the level of p-Akt in GBM. Semi-quantification of the blots confirmed a significant downregulation of PDCD10 protein level in GBM (b), which was inversely correlated to an activation of Akt (c). The level of GFAP was not significantly different among the control (c), astrocytoma grade II (Astro II) and GBM (d) group. e A representative blot showed the expression of PDCD10, phosphor-Akt (p-Akt), and GFAP in control (c), Astro II and GBM. * p < 0.05, ** p < 0.01 and *** p < 0.001, compared to c

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BMC Cancer

ISSN: 1471-2407

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