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Table 1 Patients’ demographic and baseline clinical characteristics (n = 89)

From: Retreatment with anti-EGFR based therapies in metastatic colorectal cancer: impact of intervening time interval and prior anti-EGFR response

Characteristic

Count (%)

Gender, n (%)

  Male

45 (49)

  Female

44 (51)

Age, n (%)

  < 60 years

57 (64)

  ≥ 60 years

32 (36)

Race, n (%)

  Non-Hispanic White

63 (71)

  African-American

18 (20)

  Hispanic

8 (9)

Performance status, n (%)

  0

35 (39)

  1

49 (55)

  2

5 (6)

Histological grade

  Well

3 (3)

  Moderate

69 (78)

  Poor

17 (19)

Number of metastatic sites

< 3

42 (47)

≥ 3

47 (53)

Serum albumin

  Normal

72 (81)

  Low (<3.5 g/dL)

17 (19)

Serum LDH

  Normal

19 (21)

  Elevated (>618 IU/L)

70 (79)

RMH Score

  < 2

43 (48)

  ≥ 2

46 (52)

KRAS exon 2 wild-typea

89 (100)

  KRAS non-exon 2 mutations (n = 70)

0

  NRAS mutations (n = 23)

0

  BRAF V600E mutation (n = 64)

0

  PIK3CA mutations (n = 37)

6

  1. aKRAS exon 2 wild-type status included codons 12 and 13 (exon 2); non-exon 2 KRAS mutations included exon 3 in 55 cases and exon 3 + 4 in 15 cases; NRAS mutations included exons 2 in 23, exon 3 in 17 and exon 4 in 6; PIK3CA mutations included hotspots within exons 9 and 20