Fig. 4
From: Critical role of CDK11p58 in human breast cancer growth and angiogenesis
Regulation of VEGF signaling by CDK11p58. (a) qRT-PCR analysis of VEGF mRNA in breast cancer cells MDA-MB-231 and T47D. **P < 0.01 CDK11p58 group vs control group. (b) After transfection of CDK11p58 expression for 48 h, luciferase activity of VEGF promoter reporters was detected in 293 T cells. **P < 0.01 CDK11p58 vs control vector. (c) Western blot analysis of angiogenesis-related proteins by CDK11p58. (d) The luciferase activity of VEGF promoter reporters with CDK11p58 expression and CDK11p58 mutant expression in T47D cells. (e) Western blot analysis of angiogenesis related proteins by CDK11p58 and its mutations in MDA-MB231