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Table 4 Median PFS (by RECIST) and median OS with other treatments for advanced SFT

From: Efficacy of trabectedin in malignant solitary fibrous tumors: a retrospective analysis from the French Sarcoma Group

Reference

n =

Regimen

Front-line/ Further-line

Median f-u (months)

Median PFS (months)

Median OS (months)

Stacchiotti [6]

31

Anthracycline-based chemo.

25/6

-

4 (range : 2–15) (front-line : 4)

11.5 (range : 3–50)

19

High dose ifosfamide single agent

11/8

-

3 (range : 2–9) (front-line : 3 (range : 2–9))

11 (range : 3–50)

Park [5]

21a

Conventional chemo. (anthracycline-based/gemcitabine-based/paclitaxel : 15/5/5)

18/7

-

4.6 (95 % CI = 3.7–5.6) (front-line: 4.6 (95 % CI = 4–5.3))

22.8 (95 % CI = 3.1–42.6)

Stacchiotti [7]

8

Dacarbazine

0/8

-

7 (range : 2–12)

-

Park [9]

14

Bevacizumab + temozolomide

9/5

34

10.8 (95 % CI = 8.13-not reached)

24.3

Stacchiotti [10]

35

Sunitinib

10/25

-

6 (95 % CI = 4.03–8.01)

16 (95 % CI = 12.07–25.9)

Valentin [11]

5

Sorafenib

0/5

-

-

19.7

  1. f-u follow-up, PFS progression-free survival, OS overall survival
  2. aOf 21 patients, 4 received more than one regimen of chemotherapy, for a total of 25 treatments