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Table 4 Plasma TBARS concentration in all the individuals (cases and controls), data stratified according to the genotype

From: Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

Polymorphism Genotype N TBARS concentration [μmol/L] p a (ANOVA) p b (vs wild type homozygote)
GPX1 (rs1050450) Pro/Pro 148 2.32 (1.80–3.09) 0.0527  
Pro/Leu 136 2.15 (1.69–2.64)
Leu/Leu 35 2.29 (1.75–2.94)
Pro/Leu + Leu/Leu 171 2.18 (1.70–2.73)   0.0320
GPX4 (rs713041) CC 109 2.23 (1.82–2.85) 0.4266  
CT 156 2.21 (1.75–2.89)
TT 54 2.38 (1.86–3.07)
CT + TT 210 2.34 (1.76–2.94)   0.3237
SEPP1 (rs3877899)c Ala/Ala 203 2.26 (1.76–2.94) 0.9393  
Ala/Thr 99 2.21 (1.74–2.87)
Thr/Thr 15 2.05 (1.65–2.93)
Ala/Thr + Thr/Thr 114 2.19 (1.74–2.87)   0.7802
SEP15 (rs5859) GG 185 2.26 (1.78–2.93) 0.8028  
GA 112 2.22 (1.69–2.92)
AA 22 2.03 (1.75–2.86)
GA + AA 134 2.21 (1.73–2.89)   0.5357
SOD2 (rs4880) Ala/Ala 79 2.32 (178–3.00) 0.8902  
Ala/Val 167 2.23 (1.76–2.87)
Val/Val 73 2.22 (1.69–2.92)
  Ala/Val + Val/Val 240 2.23 (1.74–2.88)   0.6891
  1. Data expressed as median values and (25 and 75 % percentiles). Significant p values are presented in bold
  2. athe Kruskal-Wallis test
  3. bthe Mann–Whitney test
  4. cgenotype status was unknown in the case of 2 individuals