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Table 4 Plasma TBARS concentration in all the individuals (cases and controls), data stratified according to the genotype

From: Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

Polymorphism

Genotype

N

TBARS concentration [μmol/L]

p a (ANOVA)

p b (vs wild type homozygote)

GPX1 (rs1050450)

Pro/Pro

148

2.32 (1.80–3.09)

0.0527

 

Pro/Leu

136

2.15 (1.69–2.64)

Leu/Leu

35

2.29 (1.75–2.94)

Pro/Leu + Leu/Leu

171

2.18 (1.70–2.73)

 

0.0320

GPX4 (rs713041)

CC

109

2.23 (1.82–2.85)

0.4266

 

CT

156

2.21 (1.75–2.89)

TT

54

2.38 (1.86–3.07)

CT + TT

210

2.34 (1.76–2.94)

 

0.3237

SEPP1 (rs3877899)c

Ala/Ala

203

2.26 (1.76–2.94)

0.9393

 

Ala/Thr

99

2.21 (1.74–2.87)

Thr/Thr

15

2.05 (1.65–2.93)

Ala/Thr + Thr/Thr

114

2.19 (1.74–2.87)

 

0.7802

SEP15 (rs5859)

GG

185

2.26 (1.78–2.93)

0.8028

 

GA

112

2.22 (1.69–2.92)

AA

22

2.03 (1.75–2.86)

GA + AA

134

2.21 (1.73–2.89)

 

0.5357

SOD2 (rs4880)

Ala/Ala

79

2.32 (178–3.00)

0.8902

 

Ala/Val

167

2.23 (1.76–2.87)

Val/Val

73

2.22 (1.69–2.92)

 

Ala/Val + Val/Val

240

2.23 (1.74–2.88)

 

0.6891

  1. Data expressed as median values and (25 and 75 % percentiles). Significant p values are presented in bold
  2. athe Kruskal-Wallis test
  3. bthe Mann–Whitney test
  4. cgenotype status was unknown in the case of 2 individuals