Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

Table 3 Oxidative stress parameters in the breast cancer cases and controls

Parameter	Cases (n = 136)	Controls (n = 183)	p ^a (vs controls)
GPx1 activity [U/g Hb]	22.3 ± 5.5 (11.1–35.0)	20.5 ± 4.7 (10.7–29.7)	0.0036
GPx3 activity [U/mL]	0.189 ± 0.037 (0.108–0.308)	0.191 ± 0.032 (0.125–0.297)	0.7491
SOD1 activity [U/mg Hb]	6.84 ± 1.24 (4.48–11.53)	6.90 ± 1.52 (3.03–10.91)	0.8590
Cp activity [g/L]	0.58 ± 0.18 (0.13–1.05)	0.66 ± 0.21 (0.31–1.75)	0.0005
TBARS concentration [μmol/L]	2.62 ± 0.96 (1.01–5.27)	2.24 ± 0.83 (1.00–5.90)	0.0003
Se concentration [μg/L]	55.2 ± 14.7 (23.2–99.9)	57.0 ± 11.8 (29.1–97.7)	0.1791

Data expressed as mean ± standard deviation and (range). Significant p values are presented in bold
^athe Mann–Whitney test

ISSN: 1471-2407