Fig. 8
From: Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition
The addition of JAK1i (1 μM) resulted in less repair of radiation-induced DNA dsbs at 6 and 24 h following radiation (2 Gy) compared to cetuximab (0.5 μg/ml) and radiation without JAK1i as measured by the neutral comet assay in all four cell lines. Top. The mean tail moment for 6 h of treatments alone or proceeded by radiation. Bottom. The mean tail moment for 24 h. Following treatment, exponentially growing cells were collected and processed for single-cell gel electrophoresis assay (Trevigen’s Comet Assay)