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Table 3 Association statistics for combined polymorphisms of CASP8 (− 652 6 N ins/del), FasR-1377 (G > A), FasR-670 (A > G) and FasL-844 (T > C) for HSV-2 infection status only in controls

From: The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa

Combined Polymorphisms

HSV-2 infected Frequency (n = 164)

HSV-2 non-infected Frequency (n = 99)

Combined Polymorphism Score

P-value

Casp8 + FasR-1377 (global P = 0.134)

 −652 6 N ins and A

7

12

−2.28

0.023

Casp8 + FasR-1377 + FasR-670 (global P = 0.164)

 −652 6 N ins, A and G

7

12

−2.17

0.03

Casp8 + FasR-1377 + FasR-670 + FasL-844 (global P = 0.324)

 −652 6 N ins, A, G and T

16

22

−2.13

0.033

  1. P-values and Combined Polymorphism Scores (CPSs) are for test of combined polymorphism association with HSV-2 infection in controls, adjusted for ethnicity and smoking. P-values next to combined polymorphism names are for joint model, others are for CPSs of specific combined polymorphism compared to a reference combined polymorphism (not shown here)
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BMC Cancer

ISSN: 1471-2407

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