The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa

Table 1 Distribution of characteristics of cervical cancer cases and control subjects

Characteristics	Cases		Controls		P-value^#
Characteristics	Black	Mixed-ancestry	Black	Mixed-ancestry	P-value^#
Number of subjects	104	338	52	226
Age (years), mean ± SD	43.7 ± 9.3	45.9 ± 8.1	40.8 ± 8.9	45.5 ± 8.1	0.271
Smoking
Positive	82	53	44	67	0.012
Negative	22	285	8	159	0.012
HSV-2 infection
Infected	93	198	47	117	0.161
Non-infected	10	128	3	96	0.161
HIV infection
Infected	13	9	4	7	0.589
Non-infected	89	322	46	206	0.589
HPV infection
Infected			12	35	0.539
Non-infected			26	97	0.539
Abnormal cytology
Positive			12	23	0.013
Negative			39	195
High-risk HPV infection
Positive			7	32	0.862
Negative			44	186

^#P-values were based on chi square test and for black and mixed-ancestry combined

ISSN: 1471-2407