Skip to main content

Advertisement

Table 6 Predictive values of using methylation profiling with different algorithms to distinguish tumour origins (n = 7)

From: Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

  Methylation  
Recurrent De novo  
aCGH Recurrent 3 2 Sn = 0.60 (3/5)
De novo 1 1 Sp = 0.50 (1/2)
  PPV = 0.75 (3/4) NPV = 0.33 (1/3)  
  1. Results were scored using Bayesian inference approach
  2. NPV negative predictive value, PPV positive predictive value, Sn sensitivity, Sp specificity