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Table 6 Predictive values of using methylation profiling with different algorithms to distinguish tumour origins (n = 7)

From: Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

 

Methylation

 

Recurrent

De novo

 

aCGH

Recurrent

3

2

Sn = 0.60 (3/5)

De novo

1

1

Sp = 0.50 (1/2)

 

PPV = 0.75 (3/4)

NPV = 0.33 (1/3)

 
  1. Results were scored using Bayesian inference approach
  2. NPV negative predictive value, PPV positive predictive value, Sn sensitivity, Sp specificity
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BMC Cancer

ISSN: 1471-2407

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