Fig. 5
From: NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer
a Mean BLI signal versus time by treatment in mice exhibiting brain metastases. Treatment was initiated on day 21. Each data point represents mean ± SEM (n = 5-18 per time point). (b) Survival analysis of mice bearing brain metastases of human breast cancer and treated weekly via IV bolus (tail vein injection) with vehicle, irinotecan (50 mg/kg), NKTR-102 (10 mg/kg), or NKTR-102 (50 mg/kg), starting 21 days post intracardiac injection of tumor cells. Median survival time was 37 days for vehicle, 35 days for irinotecan, 35 days for NKTR-102 (10 mg/kg), and 74 days for NKTR-102 (50 mg/kg)