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Table 2 Significant associations between IGF1R expression and clinicopathological features of the 150 canine mammary carcinomas

From: The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Parameters Fisher’s exact test IGF1R score 2+ IGF1R score 3+
p-value OR 95 % CI p-value OR 95 % CI
Histological grade <0.001       
Grade I or II   - 1.00 - - 1.00 -
Grade III   0.007 3.86 1.49–10.99 <0.001 6.54 2.57–18.53
LVI 0.006       
Absent   - 1.00 - - 1.00 -
Present   0.87 1.08 0.44–2.68 0.01 3.11 1.32–7.62
ER expression 0.004       
Positive (≥ 10 %)   - 1.00 - - 1.00 -
Negative (< 10 %)   0.003 4.54 1.69–13.01 0.01 3.29 1.32–8.46
PR expression 0.04       
Positive (≥ 10 %)   - 1.00 - - 1.00 -
Negative (< 10 %)   0.07 2.88 0.93–9.47 0.02 4.10 1.29–14.54
Immunophenotype 0.03       
Luminal   - 1.00 - - 1.00 -
Triple Negative   0.02 2.86 1.16–7.20 0.02 2.88 1.20–7.04
  1. IGF1R score 0–1+ is considered as the reference for each parameter
  2. IGF1R Insulin-like growth factor type 1 receptor, LVI Lymphovascular Invasion, ER Estrogen Receptor, PR Progesterone Receptor, OR Odds Ratio, 95 % CI 95 % Confidence Interval