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Table 1 Characteristics of the dogs and their invasive mammary carcinomas

From: The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Parameters Data
n (%)
Total 150 (100)
Age in yrs Median 11 yrs, Range [5.1–16.3 yrs]
5.1–10.9 yrs 73 (48.7)
≥11 yrs 77 (51.3)
Tumor size  
< 2 cm 53 (36.5)
≥ 2 cm 92 (63.5)
Histological type  
Squamous cell carcinoma 6 (4)
Simple carcinoma: Anaplastic 6 (4)
Complex carcinoma 11 (7.3)
Simple carcinoma: Solid 40 (26.7)
Simple carcinoma: Tubulopapillary 87 (58)
Histological grade (Elston & Ellis)  
Grade I 19 (12.6)
Grade II 58 (38.7)
Grade III 73 (48.7)
Lymph node status  
Positive (N1) 32 (21.3)
Negative (N0) 19 (12.7)
Unknown (NX) 99 (66)
ER expression  
Positive (≥ 10 %) 35 (23.3)
Negative (< 10 %) 115 (76.7)
PR expression  
Positive (≥ 10 %) 20 (13.3)
Negative (< 10 %) 130 (86.7)
HER2  
Score 0 85 (56.7)
Score 1+ 50 (33.3)
Score 2+ 15 (10)
Score 3+ 0
CK5/6  
Positive (≥ 10 %) 89 (59.3)
Negative (< 10 %) 61 (40.7)
EGFR  
Positive (≥ 10 %) 72 (48)
Negative (< 10 %) 78 (52)
Immunophenotype  
Luminal-A 17 (11.3)
Luminal-B 30 (20)
Triple-negative basal like 70 (46.7)
Triple-negative non basal like 33 (22)
IGF1R expression  
Score 0–1+ 34 (22.7)
Score 2+ 54 (36)
Score 3+ 62 (41.3)
Survival Time in days Median 331 days, Range [2–2608]
  1. yrs years, ER Estrogen Receptor, PR Progesterone Receptor, HER2 Epidermal Growth Factor Receptor 2, CK5/6 Cytokeratin 5/6, EGFR Epidermal Growth Factor Receptor, IGF1R Insulin-like growth factor type 1 receptor