Table 1 Characteristics of the dogs and their invasive mammary carcinomas
Parameters | Data |
|---|---|
n (%) | |
Total | 150 (100) |
Age in yrs | Median 11 yrs, Range [5.1–16.3 yrs] |
5.1–10.9 yrs | 73 (48.7) |
≥11 yrs | 77 (51.3) |
Tumor size | |
< 2 cm | 53 (36.5) |
≥ 2 cm | 92 (63.5) |
Histological type | |
Squamous cell carcinoma | 6 (4) |
Simple carcinoma: Anaplastic | 6 (4) |
Complex carcinoma | 11 (7.3) |
Simple carcinoma: Solid | 40 (26.7) |
Simple carcinoma: Tubulopapillary | 87 (58) |
Histological grade (Elston & Ellis) | |
Grade I | 19 (12.6) |
Grade II | 58 (38.7) |
Grade III | 73 (48.7) |
Lymph node status | |
Positive (N1) | 32 (21.3) |
Negative (N0) | 19 (12.7) |
Unknown (NX) | 99 (66) |
ER expression | |
Positive (≥ 10 %) | 35 (23.3) |
Negative (< 10 %) | 115 (76.7) |
PR expression | |
Positive (≥ 10 %) | 20 (13.3) |
Negative (< 10 %) | 130 (86.7) |
HER2 | |
Score 0 | 85 (56.7) |
Score 1+ | 50 (33.3) |
Score 2+ | 15 (10) |
Score 3+ | 0 |
CK5/6 | |
Positive (≥ 10 %) | 89 (59.3) |
Negative (< 10 %) | 61 (40.7) |
EGFR | |
Positive (≥ 10 %) | 72 (48) |
Negative (< 10 %) | 78 (52) |
Immunophenotype | |
Luminal-A | 17 (11.3) |
Luminal-B | 30 (20) |
Triple-negative basal like | 70 (46.7) |
Triple-negative non basal like | 33 (22) |
IGF1R expression | |
Score 0–1+ | 34 (22.7) |
Score 2+ | 54 (36) |
Score 3+ | 62 (41.3) |
Survival Time in days | Median 331 days, Range [2–2608] |