Timing of administration | Day of administration | Drug dose |
---|---|---|
Arm A | Â | Â |
H0 | 1, 8, 15 | nab-paclitaxel 125Â mg/m2, 30Â min IV infusion (maximum infusion time not exceeding 40Â min) |
H + 0.5 | 1, 8, 15 | gemcitabine 1000 mg/m2 as a 30-min IV infusion |
Arm B | Â | Â |
H0 | 1, 8, 15 | nab-paclitaxel 125Â mg/m2, 30Â min IV infusion (maximum infusion time not exceeding 40Â min) |
H + 0.5 | 1, 15 | folinic acid 400 mg/m2 (leucovorin, l + d racemic form, or l form 200 mg/m2) in 250 ml glucose 5 % solution, 2-h IV infusion |
H + 2.5 | 1, 15 | 5FU bolus 400 mg/m2 in 100 ml glucose 5 % solution, 15 min IV infusion |
H + 3 | 1–2, 15–16 | 5FU continuous infusion 2400 mg/m2, 46-h IV infusion |