Table 3 Univariate and multivariate Cox proportional analysis regarding overall survival
| Â | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
Parameter | HR (95Â % CI) | P-value | HR (95Â % CI) | P-value |
Age at operation(years) | ||||
<65 | 1 (referent) | 0.220 | 1 (referent) | 0.219 |
≥65 | 1.70(0.73-4.00) |  | 2.06(0.65-6.49) |  |
Gender | ||||
Female | 1 (referent) | 0.772 | 1 (referent) | 0.615 |
Male | 1.09(0.62-1.89) | Â | 1.20(0.59-2.45) | Â |
Performance status | ||||
0 ~ 1 | 1 (referent) | 0.006 | 1 (referent) | 0.975 |
≥2 | 2.22 (1.26-3.93) |  | 0.99 (0.48-2.03) |  |
Diabetes mellitus | ||||
No | 1 (referent) | 0.943 | 1 (referent) | 0.218 |
Yes | 1.07(0.15-7.78) | Â | 0.27(0.03-2.18) | Â |
Cardiopulmonary disease | ||||
No | 1 (referent) | 0.344 | 1 (referent) | 0.342 |
Yes | 0.38(0.06-2.78) | Â | 0.33(0.03-3.27) | Â |
Ever smoked | ||||
No | 1 (referent) | 0.579 | 1 (referent) | 0.273 |
Yes | 1.23(0.60-2.52) | Â | 1.69 (0.66-4.32) | Â |
Tumor depth | ||||
Superficial | 1 (referent) | <0.001 | 1 (referent) | 0.096 |
Deep | 6.09 (2.74-13.53) | Â | 2.41(0.85-6.77) | Â |
Tumor grade | ||||
G1 | 1 (referent) | 0.002 | NA | NA |
G2 | 4.66(1.78-12.22) | <0.001 | ||
G3 | 9.27(3.16-27.20) | |||
Tumor size | ||||
<5Â cm | 1 (referent) | 0.001 | NA | NA |
≥5 cm | 2.87(1.55-5.32) | |||
Tumor site | ||||
Trunk&extremity | 1 (referent) | <0.001 | 1 (referent) | 0.002 |
head/neck&intra-abdominal | 4.48(2.57-7.81) | Â | 3.14 (1.52-6.48) | Â |
AJCC stage | ||||
IA + IB | 1 (referent) | 0.001 | 1 (referent) | 0.002 |
IIA + IIB | 5.13(1.97-13.37) | <0.001 | 3.92 (1.43-10.76) | 0.008 |
III + IV | 10.56 (3.71-30.08) |  | 7.45(2.44-22.81) |  |
Adjuvant radiotherapy | ||||
Yes | 1 (referent) | 0.798 | 1 (referent) | 0.692 |
No | 1.08 (0.60-1.95) | Â | 0.86(0.40-1.84) | Â |
Adjuvant chemocherapy | ||||
Yes | 1 (referent) | 0.320 | 1 (referent) | 0.929 |
No | 1.44 (0.70-2.97) | 1.04(0.45-2.41) | ||
PLR | ||||
<133.915z | 1 (referent) | 0.002 | 1 (referent) | 0.019 |
≥133.915 | 2.49 (1.41-4.39) | 2.60(1.17-5.74) | ||
NLR | ||||
<2.5 | 1 (referent) | <0.001 | 1 (referent) | 0.881 |
≥2.5 | 2.83 (1.61-4.99) | 1.06(0.52-2.16) | ||