Skip to main content
Fig. 8 | BMC Cancer

Fig. 8

From: Aberrant activation of NF-κB signaling in mammary epithelium leads to abnormal growth and ductal carcinoma in situ

Fig. 8

MUC1 oncoprotein is up-regulated and mislocalized in IKMV mammary epithelium. RNA was isolated from mammary glands of IKMV and control mice after 3 days of dox treatment (6 week time point). a The hyperplastic IKMV ducts have increased expression of MUC1 via qRT-PCR (n = 5 control, n = 6 IKMV samples; *p = 0.0119). b Staining for MUC1 indicates that it is properly localized to the apical surface of luminal epithelium in control ducts but it has become repositioned to the entire cell membrane in many of the cells within the IKMV hyperplastic ducts (red staining is MUC1, blue is DAPI; 40X images are shown; images at bottom are magnified to show detail)

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us