Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma

Table 3 Univariate and multivariate analyses of different prognostic parameters for overall survival of 152 glioblastoma patients

Variable	Univariate			Multivariate
Variable	P	HR	95 % CI	P	HR	95 % CI
Age (≤60 vs. >60)	0.025	1.603	1.060–2.424	0.478	1.168	0.755–1.806
KPS (≤70 vs. 80–100)	0.032	0.670	0.465–0.966	0.045	0.794	0.633–0.995
Resection (biopsy vs. STR vs. GTR)	0.047	0.800	0.641–0.997	0.110	0.738	0.509–1.071
MGMT promoter (unmethylated vs. methylated)	0.011	0.605	0.411–0.890	0.041	0.660	0.443–0.983
Pretreatment PLR (<135 vs. >135)	0.039	1.463	1.020–2.097	0.918	1.023	0.668–1.565
Pretreatment NLR (<4 vs. ≥4)	<0.001	2.139	1.464–3.125	0.002	2.068	1.304–3.277

GTR gross total resection, KPS Karnofsky Performance Scores, MGMT O(6)-methylguanine-DNA-methyltransferase, NLR Neutrophil to Lymphocyte Ratio, PLR Platelet to Lymphocyte Ratio, STR subtotal resection

ISSN: 1471-2407