Fig. 7

Schematic representing the differences between T47D and HB2 cells following exposure to doxorubicin. Activation of MRP1 and induction of chemoresistance in T47D cancer cells is Notch1 dependent and can be inhibited by DAPT, representing a potential chemo-sensitizing strategy. In HB2 cells, doxorubicin induces MRP1 expression but this is independent of Notch1 signalling (1), therefore Notch inhibitors do not impact on chemo-sensitivity