Skip to main content

Table 4 Potential avoided initial biopsies (IBx), PCa and HGPCa detection and missed rates at IBx using different threshold probabilities values

From: Optimizing the clinical utility of PCA3 to diagnose prostate cancer in initial prostate biopsy

Threshold Biopsies Biopsies PCa detected PCa delayed HGPCa detected HGPCa delayed
Probability Perforrmed, n (%) Avoided, n (%) n (%) Diagnosis, n (%) n (%) Diagnosis, n (%)
>10 % 362 (90.3 %) 39 (9.7 %) 108 (97.3 %) 3 ( 2.7 %) 43 (97.7 %) 1 ( 2.3 %)
>20 % 295 (73.6 %) 106 (26.4 %) 99 (89.2 %) 12 (10.8 %) 40 (90.9 %) 4 ( 9.1 %)
>30 % 250 (62.3 %) 151 (37.3 %) 90 (81.1 %) 21 (19.9 %) 38 (86.4 %) 6 (13.4 %)
>35 % 228 (56.9 %) 173 (43.1 %) 88 (79.3 %) 23 (20.7 %) 37 (84.1 %) 7 (15.9 %)
>40 % 204 (50.9 %) 197 (49.1 %) 84 (75.7 %) 27 (24.3 %) 37 (84.1 %) 7 (15.9 %)
>45 % 187 (46.6 %) 214 (53.4 %) 80 (72.1 %) 31 (27.9 %) 36 (81.8 %) 8 (18.2 %)
>50 % 160 (39.9 %) 241 (60.1 %) 71 (64.0 %) 40 (36.0 %) 34 (77.3 %) 10 (22.7 %)
>60 % 98 (24.4 %) 303 (75.6 %) 55 (49.5 %) 56 (50.5 %) 28 (63.6 %) 16 (36.4 %)