Fig. 3

Pharmacokinetics of tamoxifen, 4-hydroxytamoxifen, and ZB497 in mice after i.p. administration (a-c), or oral administration (d-f) at a single dose of 1 mg/kg. For i.p. administration of drugs, mice were injected with PBS containing ZB497, tamoxifen, or 4-OHT by adding appropriate amounts of individual stock solutions of the drugs dissolved in DMSO. For oral administration, mice were given oral gavage containing PBS and ethanol-dissolved ZB497, tamoxifen, or 4-OHT