Fig. 2

Main treatments and clinical and laboratory findings over the course of hospitalization. a Daily doses of spironolactone (mg, open triangles), sorafenib (mg, closed triangles), mifepristone (mg, closed squares), potassium chloride (mmol potassium, open squares), and insulin (units, open circles). b Daily doses of carvedilol (mg, open squares) and amlodipine (mg, closed squares). c Concentrations of cortisol (nmol/L, closed squares), carcinoembryonic antigen (CEA, μg/L, open squares), calcitonin (pmol/L, closed circles), adrenocorticoitropic hormone (ACTH, ng/L, open circles; values greater than 2000 ng/dL are reported as 2000 ng/L; multiply by 0.22 to convert to pmol/L), and renin (mU/L, closed triangles). Aldosterone was < 8 and < 4 ng/L (multiply by 0.277 to convert to nmol/L) on days 5 and 36, respectively. d Mean daily concentration of sodium (mmol/L, closed triangles), mean daily measurements of systolic (mmHg, open triangles) and diastolic blood pressure (mmHg, open squares), and concentration of dehydroepiandrosterone sulfate (DHEAS, closed squares, μmol/L). Dehydroepiandrosterone (DHEA) was 12 and 3.9 ng/mL on days 8 and 25, respectively (multiply by 3.47 to convert to nmol/L). Progesterone was 40.4 and 42.2 nmol/L on days 40 and 43, respectively. 17-hydroxyprogestrone was 6.2 nmol/L on day 40. e Mean daily concentration of glucose (mmol/L, closed squares) and potassium (mmol/L, open squares). f Concentrations of alkaline phosphatase (U/L, closed squares), alanine aminotransaminase (ALT, U/L, open squares), aspartate aminotransferase (AST, U/L, open circles), and total bilirubin (μmol/L, closed circles). Prothrombin time was 15.4, 17.4, 22.1, 31.5, and 37.6 s on days 16, 27, 36, 43, 48, respectively. Albumin was 35, 32, and 19.7 g/L on days 1, 21, and 41, respectively