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Table 3 Effects of verapamil on the sensitivity of human ovarian carcinoma cell lines to cytochalasin congeners

From: Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro

Cell line SKOV3 SKVCR0.015 SKVCR0.1 SKVLB1
IC concentrations (μM) at 96 h IC90 FS IC90 FS IC90 FS IC90 FS
Cytochalasin A
 Alone 0.8 - 0.8 - 0.2 - 0.75 -
 15 μM Verapamil 0.4 2 0.4 2 0.1 2 ND  
 30 μM Verapamil 0.4 2 0.4 2 0.1 2 0.75 -
Cytochalasin B
 Alone 2.3 - 1.5 - 1.1 - 3 -
 15 μM Verapamil 1.2 1.9 1 1.5 0.55 2 ND  
 30 μM Verapamil 1.1 2 0.75 2 0.55 2 2 1.5
21, 22-Dihydrocytochalasin B
 Alone 3 - 2.4 - 1.6 - 5 -
 15 μM Verapamil 2.5 1.2 1.5 1.6 1.0 1.6 ND  
 30 μM Verapamil 2 1.5 1.3 1.8 0.8 2 3.2 1.57
Cytochalasin C
 Alone 0.25 - 0.25 - 0.25 - 8  
 15 μM Verapamil ND   ND   ND   ND  
 30 μM Verapamil 0.25 1 0.25 1 0.125 2 0.25 32
Cytochalasin D
 Alone 0.08 - 0.08 - 0.1 - 8  
 15 μM Verapamil 0.08 1 0.06 1.5 0.1 1 ND  
 30 μM Verapamil 0.08 1 0.04 2 0.075 1.5 0.13 64
  1. ND not determined, FS fold sensitization