Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro

Table 3 Effects of verapamil on the sensitivity of human ovarian carcinoma cell lines to cytochalasin congeners

Cell line	SKOV3		SKVCR0.015		SKVCR0.1		SKVLB1
IC concentrations (μM) at 96 h	IC₉₀	FS	IC₉₀	FS	IC₉₀	FS	IC₉₀	FS
Cytochalasin A
Alone	0.8	-	0.8	-	0.2	-	0.75	-
15 μM Verapamil	0.4	2	0.4	2	0.1	2	ND
30 μM Verapamil	0.4	2	0.4	2	0.1	2	0.75	-
Cytochalasin B
Alone	2.3	-	1.5	-	1.1	-	3	-
15 μM Verapamil	1.2	1.9	1	1.5	0.55	2	ND
30 μM Verapamil	1.1	2	0.75	2	0.55	2	2	1.5
21, 22-Dihydrocytochalasin B
Alone	3	-	2.4	-	1.6	-	5	-
15 μM Verapamil	2.5	1.2	1.5	1.6	1.0	1.6	ND
30 μM Verapamil	2	1.5	1.3	1.8	0.8	2	3.2	1.57
Cytochalasin C
Alone	0.25	-	0.25	-	0.25	-	8
15 μM Verapamil	ND		ND		ND		ND
30 μM Verapamil	0.25	1	0.25	1	0.125	2	0.25	32
Cytochalasin D
Alone	0.08	-	0.08	-	0.1	-	8
15 μM Verapamil	0.08	1	0.06	1.5	0.1	1	ND
30 μM Verapamil	0.08	1	0.04	2	0.075	1.5	0.13	64

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