Fig. 2

Comparison of clinically approved chemotherapeutic agents and cytochalasin congeners against SKOV3 drug sensitive and SKVLB1 multidrug resistant human ovarian carcinomas. Abbreviations used are as follows: ADR (Adriamycin; doxorubicin), Tax (paclitaxel), VBL (vinblastine), CA (cytochalasin A), CB (cytochalasin B), DiHCB (21,22-dihydrocytochalasin B), CC (cytochalasin C), CD (cytochalasin D), CE (cytochalasin E), CH (cytochalasin H), and CJ (cytochalasin J). The concentration of each agent in nM needed to produce an IC₉₀ value at 96 h for either cell line is represented on a logarithmic scale. The resistance index (RI) of each compound against SKVLB1 is indicated in bold underneath the abbreviations