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Fig. 2 | BMC Cancer

Fig. 2

From: Neoadjuvant administration of Semliki Forest virus expressing interleukin-12 combined with attenuated Salmonella eradicates breast cancer metastasis and achieves long-term survival in immunocompetent mice

Fig. 2

Antitumor effect of SFV-IL-12 in 4T1 tumor bearing mice. Two doses of SFV-LacZ or SFV-IL-12 (2×108 vp in 50 μl PBS) were i.t. injected at days 10 and 13 after 4T1 cells inoculation. An equivalent volume of PBS was administered to control animals a Tumor size progression was measured every 3-6 days and mean tumor volumes were calculated for each group (n = 6). b Kaplan–Meier plot shows the survival rate of the same mice. c Pictures of representative tumors 21 days after 4T1 cells inoculation showing the external aspect (upper panel) and interior tumor region (lower panel). A reduced volume and vasculature was observed in treated mice compared to control mice. d An additional group of treated and control animals were sacrificed 35 days after tumor cells inoculation and 4T1 lung metastases were quantified as described in Methods. Non-significant (n.s), p< 0.01 (**); p< 0.001 (***)

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BMC Cancer

ISSN: 1471-2407

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