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Table 2 Cytokine levels at baseline before and at the beginning of the first clinical symptoms of veno-occlusive-disease and organ specific graft-versus-host disease

From: Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation

Post-transplant-adverse event Serum level Before post-transplant adverse event Post-transplant adverse event  
   Median Range Median Range P-value
VOD IL-6 pg/ml 3.150 2.0 – 28.0 69.850 7.7 – 197.0 0.0313
  IL-8 pg/ml 18.4 5.0 – 54.2 105 13.6 – 200.0 0.0156
  IL-10 pg/ml 3.55 2.4 – 4.7 6.20 4.3 – 20.4 n.d.
  sIL-2R U/ml 1519.0 397 – 3796 3218.0 1934 – 4666 0.3750
  IL-1 ß ng/ml 0.260 0.15 – 0.39 0.335 0.1 – 0.47 0.7500
  TNF-α pg/ml 8.00 7.5 – 21.8 22.30 10.5 – 103 0.0313
Acute liver GvHD IL-6 pg/ml 2.0 2.0 – 2.0 28.1 27.5 – 28.7 n.d.
  IL-8 pg/ml 20 5.0 – 35.0 526.5 460.0 – 593.0 n.d.
  IL-10 pg/ml 2.00 2.0 – 2.0 135.90 98.8 – 173.0 n.d.
  sIL-2R U/ml 823 823 – 823 5705.0 2483 – 8927 n.d.
  TNF-α pg/ml 4.00 4.0 – 4.0 50.35 32.2 – 68.5 n.d.
Acute intestinal GvHD II-IV IL-6 pg/ml 3.3 2.0 – 26.0 24.3 2.0 – 254.0 0.0010
  IL-8 pg/ml 26.65 5.0 – 5702 33.6 10.7 – 460.0 0.2036
  IL-10 pg/ml 3.20 2.0 – 7.9 46.25 12.4 – 173 0.0039
  sIL-2R U/ml 823.5 397 – 2393 2321.0 1296 – 3586 0.0020
  IL-1 ß ng/ml 0.21 0.22 – 0.41 0.21 0.17 – 0.31 0.5000
  TNF-α pg/ml 7.20 5.2 – 19.90 28.05 12.4 – 90.6 0.0020
Acute skin GvHD II-IV IL-6 pg/ml 2.15 2.0 – 7.4 8.3 2.5 – 83.2 0.0010
  IL-8 pg/ml 10.4 5.0 – 40.0 11.9 5.0 – 47.9 0.2783
  IL-10 pg/ml 4.90 2.0 – 7.7 6.60 1.9 – 278.0 0.9453
  sIL-2R U/ml 930.5 397 – 2831 1846.0 918 – 8540 0.0049
  IL-1 ß ng/ml 0.18 0.1 – 0.39 0.34 0.23 – 0.36 0.5000
  TNF-α pg/ml 7.20 4.0 – 17.0 18.20 11.2 – 35.7 0.0020
  1. *P-value: statistical comparison between baseline measurements and during post-transplant adverse events by the Wilcoxon matched pairs signed rank test; n.d. = not determined due to small sample size